She once wished that their relationship would take a few steps, but Garfield doesn't seem to notice. Garfield once quipped in the early strips, that he and Arlene have an apparent love-hate relationship: Garfield loves himself, and Arlene hates that. Once, while Garfield was waiting for Arlene to come to a date, another beautiful cat walked up to Garfield and greeted him. At the same time, Arlene appeared, and quickly got enraged. In the next strip, Arlene called Garfield a "cad", but Garfield cleared up the misunderstanding, and Arlene forgave him.
Although she never appeared in the animated series (with the exception of a cameo appearance in the episode, "Feline Felon".
In the book, "Garfield's Judgement Day", it was revealed that she was a stray cat, which she had never revealed to Garfield, until emergency situations brought it to light. She is voiced by Debra Messing.